Abstract
Based on empirical evidence that suggests that failing to recognize a stimulus as emotionally relevant results in hypoactivity of the orexinergic cells in the hypothalamus, this article proposes a physiological model of boredom that makes depression a consequence of a chronic reduction of monoamines in the brain combined with increased levels of norepinephrine and cortisol. The studies proposed here look to find supportive evidence for two assumptions of this model: 1. That the negative affect associated with boredom results from a conscious assessment of the situation; 2. That activity of the orexinergic neurons can increase both positive and negative affect, depending on the assessed valence of a stimulus.